Changes and Significance of Serum IL-26,IL-4,and LDH Levels in Patients with Colorectal Cancer

JIN Hongyu; WU Xiaoyan

doi:10.14033/j.cnki.cfmr.2025.23.003

Abstract：Objective:To explore the changes and significance of serum interleukin-26(IL-26),interleukin-4(IL-4),lactate dehydrogenase(LDH)levels in patients with colorectal cancer.Method:A retrospective analysis was conducted on the clinical data of 86 patients with colorectal cancer who were diagnosed and treated in Qingpu District Hospital of Traditional Chinese Medicine,Shanghai from June 2022 to September 2024.The levels of serum IL-26,IL-4,and LDH indicators in patients with different clinical characteristics were compared,and the correlations between serum IL-26,IL-4,and LDH indicators and different clinical characteristics of colorectal cancer were analyzed.Result:There were statistically significant differences in IL-26,IL-4 and LDH among colorectal cancer patients with different clinical stages,lymph node metastasis conditions and differentiation degrees(P<0.05).Among them,the higher the clinical stage of the patients,the higher the levels of IL-26,IL-4 and LDH indicators.The levels of IL-26,IL-4 and LDH indicators in patients with metastasis were higher than those in patients without metastasis.The lower the degree of differentiation in patients,the higher the levels of IL-26,IL-4 and LDH indicators.The indicators of IL-26,IL-4 and LDH were positively correlated with the clinical stage of patients with colorectal cancer(r>0,P<0.05).The indicators of IL-26,IL-4 and LDH were negatively correlated with the lymph node metastasis and differentiation degree of patients with colorectal cancer(r<0,P<0.05).Conclusion:The changes in the levels of serum IL-26,IL-4 and LDH in patients with colorectal cancer can reflect the condition of the patients.The higher the levels of IL-26,IL-4 and LDH indicators,the higher the clinical stage of the patients with colorectal cancer,the higher the risk of lymph node metastasis and the lower the degree of differentiation.