Effect of Sini Sanjie Decoction Combined with Leuprelin on Children with Precocious Puberty

LI Liyuan

doi:10.14033/j.cnki.cfmr.2025.22.007

Abstract：Objective:To explore the clinical effect of Sini Sanjie Decoction combined with leuprelin in the treatment of children with precocious puberty.Method:A comparative analysis trial was carried out in Jinjiang Hospital from January 2022 to June 2024,and 100 female children with precocious puberty were selected during the period.They were randomly divided into the observation group and the control group by using the medical record number table method,with 50 children in both groups.The control group was treated with leuprelin,and the observation group was treated with Sini Sanjietang combined with leuprelin.The clinical effective rate,sex hormone level,ovarian volume,uterine volume,follicle diameter,bone age index,serum factor level and incidence of adverse reactions were compared between the two groups.Result:There was statistically significant difference in the clinical effective rate between the two groups(P<0.05).There was statistically significant difference in sex hormone levels between the two groups(P<0.05).There were statistically significant differences in ovarian volume,uterine volume,follicular diameter and bone age index data between the two groups(P<0.05).The comparison of the serum factor level data of the two groups showed that after treatment,the adiponectin(ADPN)data of the observation group was significantly higher than that of the control group,and the serum neurokinin B(NKB)and insulin-like growth factor 1(IGF-1)data were significantly lower than those of the control group,with statistically significant difference(P<0.05).Conclusion:For children with precocious puberty,the treatment intervention with Sini Sanjie Decoction combined with leprorelin can achieve relatively ideal results.After the treatment,the sex hormone levels of the children tend to be normal,the ovaries and uterus shrink to varying degrees.The bone age and follicular diameter indicators are similar to those of healthy children,the levels of multiple serum factors improve,with no serious adverse reactions.