Efficacy of GnRH-a Combined with Laparoscopic Cyst Removal in the Treatment of Ovarian Endometriosis Cysts

HE Li; BU Xiaoting

doi:10.14033/j.cnki.cfmr.2025.19.003

Abstract：Objective:To study the therapeutic effect of gonadotropin-releasing hormone agonist(GnRH-a)combined with laparoscopic cyst removal for ovarian endometriosis.Method:84 patients with ovarian endometriosis cysts admitted to the Obstetrics and Gynecology Department of Chenggu County Hospital from January 2023 to January 2024 were randomly divided into an observation group(n=43)and a control group(n=41).Both groups underwent laparoscopic cystectomy treatment,with the control group receiving a combination of gestrel and the observation group receiving a combination of GnRH-a.The efficacy,sex hormones[estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH)],immune function indicators[T lymphocyte subsets(CD4+,CD8+,CD4+/CD8+)],adverse reactions,pregnancy and recurrence rates between two groups were compared.Result:The effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The levels of E2,LH,FSH,CD4+,CD4+/CD8+,incidence of adverse reactions,and recurrence rate in the observation group were lower than those in the control group,while the levels of CD8+and pregnancy rate were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion:Laparoscopic cystectomy combined with GnRH-a for the treatment of ovarian endometriosis cysts can enhance immune function,inhibit hormone release,and have a low postoperative recurrence rate and few adverse reactions.The medication is safe and reliable,and can also improve pregnancy rates.