Correlation Analysis of Blood Glucose,Blood Lipids and Liver Function in Patients with Cirrhosis

DONG Zigang

doi:10.14033/j.cnki.cfmr.2025.18.010

Abstract：Objective:To explore the correlation between blood glucose,lipid levels,and liver function in patients with liver cirrhosis,aiming to provide new ideas and methods for the diagnosis and treatment of liver cirrhosis.Method:975 patients with cirrhosis treated in the Second People's Hospital of Baoji City from March 2021 to January 2024 and 500 normal individuals who underwent physical examinations during the same time were selected as the study objects.469 patients with Child-Pugh grade A and B were included in the good group,506 patients with Child-Pugh grade C were included in the worsening group.and 500 patients with normal physical examination were included in the control group.The levels of blood glucose,blood lipids and liver function indexes were compared among the three groups.Pearson correlation analysis was used to investigate the correlation between blood glucose,blood lipids and liver function.Multivariate regression was used to analyze the relationship between blood glucose,blood lipid and abnormal liver function.Result:There were statistically significant differences in fasting insulin(FINS),2-hour postprandial glucose(PPG),post-prandial insulin(PINS),high-density lipoprotein cholesterol(HDL-C)and total cholesterol(TC)levels among three groups(P<0.05).There was no significant difference in fasting blood glucose(FBG),low density lipoprotein cholesterol(LDL-C)and triglyceride(TG)levels among the three groups(P>0.05).There were significant differences in liver function indexes among the three groups(P<0.05).The levels of FINS,PPG,PINS,HDL-C and TC in patients with cirrhosis were closely correlated with liver function indexes glutamic-pyruginous aminotransferase(ALT),albumin(ALB),total bilirubin(TBIL)and prothrombin time(PT).Conclusion:Blood glucose and lipid levels are closely related to liver function in patients with cirrhosis.High levels of FINS,PPG,PINS and TC and low levels of HDL-C may indicate the deterioration of liver function in patients with cirrhosis.