The Effectiveness and Safety Analysis of Salbutamol Combined with Budesonide Micro Pump Atomizing Inhalation in the Treatment of Infantile Asthma
JIAN Zhongcheng
JIAN Jiaojiao
Abstract：Objective:To explore the clinical effect of aerosol inhalation of salbutamol and budesonide micro pump for infantile asthma.Method:A total of 80 children with asthma in infants and young children treated in Longyan People's Hospital from January 2021 to January 2024 were selected as research objects and divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with budesonide,and the observation group was treated with salbutamol.The clinical efficacy,resolution time,length of hospital stay,lung function,inflammatory factors and adverse reactions were compared between the two groups.Result:The total effective rate of observation group was higher than that of control group.The time of dyspnea,cough,wheezing and wheezing in the observation group were shorter than those in the control group.After treatment,the peak expiratory flow rate(PEF),forced expiratory volume in the first second(FEV1),forced vital capacity(FVC)and expiratory flow rate when forced to exhale 50%of vital capacity(FVE50%)in the observation group were higher than those in the control group.The levels of interleukin-1β(IL-1β)and interleukin-12(IL-12)in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:In the clinical treatment of infant asthma,salbutamol and budesonide are effective,can improve the symptoms and lung function of children,reduce the level of inflammatory factors in the body,and are relatively safe.
Keywords：Infantile asthmaSalbutamolBudesonideMicro pump atomizing inhalationResolution timeLength of hospital stayPulmonary functionInflammatory factorsAdverse reactions
Publication Date：2025-06-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 32-35 )