The Influence of Albumin-Bound Paclitaxel on the Recurrence and Metastasis Indicators and Ultrasound Parameters of Patients with Refractory Breast Cancer
HUANG Sufang
WANG Qingqing
HUANG Qiuling
SUN Yayi
DAI Li
Abstract：Objective:To explore the influence of albumin-bound paclitaxel on the recurrence and metastasis indicators and ultrasound parameters of patients with refractory breast cancer.Method:A total of 80 patients with refractory breast cancer admitted to Chinese People,s Liberation.Joint Logistic Support Force No.910 Hospital from February 2022 to December 2023 were selected and divided into thewere selected,and they were divided into control group(n=40)and observation group(n=40)according to the random number table method.The control group was treated with Pemetrexed,while the observation group were treated with albumin-bound paclitaxel.The disease control rate,incidence of toxic and side effects,recurrence and metastasis indicators before and after treatment[serum vascular endothelial growth factor(VEGF),matrix metalloproteinase-9(MMP-9),and angiopoietin-like protein-2(Angptl-2)]and ultrasound parameters[blood flow parameters such as peak systolic velocity(PSV),end-diastolic velocity(EDV),resistance Index(RI),minimum elastic modulus(Emin)and maximum elastic modulus(Emax)]were compared between the two groups.Result:The disease control rate in the observation group was significantly higher than that in the control group,and the incidence of toxic and side effects was lower than that in the control group.The difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the recurrence and metastasis indicators and ultrasound parameters between the two groups(P>0.05).After treatment,the recurrence and metastasis indicators and ultrasound parameters in the observation group were lower than those in the control group,and the recurrence and metastasis indicators and ultrasound parameters in both groups after treatment were lower than those before treatment,with statistically significant differences(P<0.05).Conclusion:Albumin-bound paclitaxel has a good efficacy in patients with refractory breast cancer,high application safety,and can significantly improve the recurrence and metastasis indicators and ultrasound parameters of patients.
Keywords：Albumin-bound paclitaxelRefractory breast cancerRecurrence Metastasis indicatorsUltrasound parameters
Publication Date：2025-06-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 28-31 )