Analysis of the Incidence and Risk Factors of Vascular Reocclusion in Patients with Acute Cerebral Infarction after Intravenous Thrombolysis with Alteplase

ZHU Yuan

doi:10.14033/j.cnki.cfmr.2025.18.007

Abstract：Objective:To investigate the incidence and risk factors of vascular reocclusion in patients with acute cerebral infarction(ACI)after intravenous thrombolysis with alteplase.Method:The clinical data of 80 patients with ACI admitted to Xinyi People's Hospital from May 2020 to May 2024 was retrospectively analyzed and studied.According to the situation of vascular re-occlusion after thrombolysis,they were divided into vascular re-occlusion group and non vascular re-occlusion group.All patients'basic data such as age,sex,body mass index,onset to thrombolysis time,hypertension,diabetes,smoking history,alcohol drinking history,National Institutes of Health Stroke Scale(NIHSS)score before thrombolysis,and history of atrial fibrillation were collected.Logistic regression analysis was carried out to analyse the risk factors of vascular re-occlusion after thrombolysis.Result:Vascular re-occlusion occurred in 21 of the 80 ACI patients,with an incidence of 26.25%(21/80).Single result factor showed that age,onset time to thrombolysis,diabetes combined,NIHSS score before thrombolysis were related to vascular re-occlusion after intravenous thrombolysis,and the difference was statistically significant(P<0.05).Gender,body mass index,combined hypertension,smoking history,drinking history,and history of atrial fibrillation were not correlated with vascular re-occlusion after intravenous thrombolysis,and there was no statistical significance(P>0.05).Multivariate result showed that age≥65 years old,time from onset to thrombolysis≥3 h,combined diabetes mellitus,and pre-thrombolysis NIHSS score≥13 were risk factors for vascular re-occlusion after intravenous thrombolytic therapy in ACI patients(OR>1,P<0.05).Conclusion:Vascular re-occlusion in ACI patients after intravenous thrombolysis is influenced by factors such as age and the time from onset to thrombolysis,and requires high attention.Early targeted prevention and treatment should be carried out to ensure the effectiveness of thrombolysis.