Analysis of the Combined Predictive Value of Serum PGⅠ,PGⅡ,G-17 Expression and Changes in Gastric Tissue CXCL5 for Gastric Precancerous Lesions

YU Haiting; XING Rui; LIN Yongliang

doi:10.14033/j.cnki.cfmr.2025.18.006

Abstract：Objective:To explore the combined predictive value of serum pepsinogen Ⅰ(PG Ⅰ),serum pepsinogen Ⅱ(PG Ⅱ),gastrin-17(G-17)expression and changes in gastric tissue C-X-C motif chemokine ligand 5(CXCL5)for gastric precancerous lesions.Method:The clinical data of 300 patients undergoing gastroscopy for gastric diseases admitted to Yangjiang People's Hospital from August 2023 to November 2024 were retrospectively analyzed.According to the results of gastroscopy and pathological examination,they were divided into gastric cancer group(n=120)and gastric precancerous lesion group(n=180),and 100 healthy subjects in the same period were selected as control group(n=100).The levels of serum PG Ⅰ,PG Ⅱ,G-17 and gastric CXCL5 were compared among the three groups,and the correlation between PG Ⅰ,PG Ⅱ,G-17 and gastric CXCL5 and gastric precancerous lesions was investigated by Pearson and Spearman correlation analysis.Logistic regression was used to analyze the influencing factors of gastric cancer prelesions.The predictive value of serum PGⅠ,PGⅡ,G-17 levels and gastric CXCL5 combined with receiver operating characteristic curve(ROC)was used to detect the precancerous lesions of gastric cancer.Result:The ratio of PGⅠand PGⅡ/PGⅡ in control group was higher than that in precancerous gastric cancer group and gastric cancer group,and the level of PGⅡand G-17 and the positive expression rate of CXCL5 in gastric tissue in gastric cancer group were higher than those in precancerous gastric cancer group and control group,with statistical significance(P<0.05).PG-Ⅰ was negatively correlated with precancerous lesions,while PG-Ⅱ,G-17 and CXCL5 were positively correlated with precancerous lesions.PG Ⅰ,PG Ⅱ,G-17 and CXCL5 were independent factors of gastric precancerous lesions.The area under ROC curve(AUC)was 0.996,the sensitivity was 0.967,and the specificity was 0.983.Serum PGⅠ,PGⅡ,G-17 and gastric CXCL5 had high predictive value for the prediction model of gastric precancerous lesions.Conclusion:The combined detection of serum PGⅠ,PGⅡ,G-17 and gastric CXCL5 is helpful for the early diagnosis of gastric precancerous lesions.