Effect of Ropivacaine Combined with Dexmedetomidine for Transversus Abdominis Plane Block on Patients Undergoing Laparoscopic Cholecystectomy

LIANG Dangui; LI Yaoyao; WU Yuehua

doi:10.14033/j.cnki.cfmr.2025.17.009

Abstract：Objective:To analyze the effect of Ropivacaine combined with Dexmedetomidine for transversus abdominis plane block on patients undergoing laparoscopic cholecystectomy.Method:A total of 118 patients who underwent laparoscopic cholecystectomy in Yangjiang People's Hospital from March 2022 to March 2024 were selected,they were divided into control group and study group according to the anesthesia method,with 59 cases in each group.The control group was injected with Dexmedetomidine,and the study group was injected with Ropivacaine combined with Dexmedetomidine.The anesthetic effect,intestinal motor function,hemorheology,oxidative stress,inflammatory factors,autonomic nerve function and postoperative adverse reactions were compared between two groups.Result:The time of spontaneous breathing recovery,complete recovery,extubation,first bowel sound recovery,first exhaust,first defecation and first eating solid food in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05);the plasma viscosity,whole blood low-cut viscosity,whole blood high-cut viscosity,malondialdehyde(MDA),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and low-frequency power(LF)in the study group at 2 h and 24 h after operation in the study group were lower than those in the control group,while total antioxidant capacity(T-AOC),superoxide dismutase(SOD),total power(TP)and high-frequency power(HF)were higher than those in the control group,and the differences were statistically significant(P<0.05);there was no significant difference in the incidence of postoperative adverse reactions between two groups(P>0.05).Conclusion:The use of Ropivacaine combined with Dexmedetomidine for transversus abdominis plane block in laparoscopic cholecystectomy can improve hemorheology and autonomic nerve function in vivo,reduce postoperative stress response,inhibit the expression of inflammatory cytokines,and promote the recovery of intestinal motor function,it has good anesthetic effect and high clinical safety.