Effects of Guizhi Poria Pills on Oxidative Stress and Inflammatory Factors in Patients with Acute Ischemic Stroke after Intravascular Therapy
GUO Fu
CHEN Jieming
WANG Xiaoyue
YU Shangzhen
Abstract：Objective:To investigate the effect of Guizhi Fuling Pills on oxidative stress and inflammatory factors in patients with acute ischemic stroke after intravascular therapy.Method:From June 2021 to June 2024,136 patients with ischemic stroke undergoing endovascular therapy in Jiangmen Wuyi Hospital of Traditional Chinese Medicine were randomly divided into control group(n=68)and observation group(n=68).The control group was given routine treatment after operation,and the observation group was treated with Guizhi Fuling Pills on this basis.Both groups were treated for 14 d.The oxidative stress indexes[superoxide dismutase(SOD),malondialdehyde(MDA)and nitric oxide(NO)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-10(IL-10)],neurological function before and after treatment and the adverse reactions during treatment were compared between the two groups.Result:After treatment,SOD and NO levels were increased and MDA levels were decreased in both groups,and SOD and NO levels were higher and MDA levels were lower in observation group than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α,IL-6 and IL-10 were decreased in both groups,and the levels were lower in the observation group than those in the control group,the differences were statistically significant(P<0.05).NIHSS scores of the two groups 7 d and 14 d of treatment were lower than before treatment,NIHSS scores of the two group at 14 d of treatment were lower than those of 7 d of treatment,the differences were statistically significant(P<0.05).At 7 d and 14 d of treatment,there were no significant differences in NIHSS scores between the two groups(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Guizhi Fuling Pills can alleviate the oxidative stress and inflammatory response after intravascular therapy in patients with acute ischemic stroke,improve the nerve function,and and do not increase the incidence of adverse reactions.
Keywords：Guizhi Fuling PillsAcute ischemic strokeIntravascular therapyReperfusion injuryOxidative stressInflammatory factorsNeurological function
Publication Date：2025-06-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 27-30 )