Efficacy and Safety of Tirofiban Combined with Coronary Intervention in the Treatment of Acute Myocardial Infarction

WU Shiping; YU Fan

doi:10.14033/j.cnki.cfmr.2025.17.004

Abstract：Objective:To explore the efficacy and safety of Tirofiban combined with coronary intervention in the treatment of acute myocardial infarction.Method:A total of 78 patients with acute myocardial infarction who admitted to the Department of Cardiology of the Second Hospital of Zhangzhou City from January 2022 to January 2024 were selected,and they were divided into the control group(n=39,routine coronary intervention)and the observation group(n=39,Tirofiban combined with coronary intervention)according to the random number table method.The cardiac function indexes[heart rate,left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF)],inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],blood lipid indexes[triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]were compared between two groups before and after treatment.Result:Before treatment,there were no significant differences in the cardiac function indexes,inflammatory factors and blood lipid indexes between two groups(P>0.05);after treatment,the heart rate,LVEDV,LVESV,the levels of hs-CRP,IL-6,TNF-α,TG,TC and LDL-C in the observation group were lower than those in the control group,and the LVEF and level of HDL-C were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Tirofiban combined with coronary intervention in patients with acute myocardial infarction can improve cardiac function,improve blood lipid index,relieve inflammatory factors and reduce adverse reactions.