Clinical Observation of Early Blood Perfusion in the Treatment of Pulmonary Contusion Complicated with Acute Lung Injury

YU Fengyou; YANG Puyun; CHEN Xiangyin; YU Kongmou; LUO Zengwen; WU Quanzhong

doi:10.14033/j.cnki.cfmr.2025.17.003

Abstract：Objective:To explore the clinical effect of early blood perfusion in the treatment of patients with pulmonary contusion complicated with acute lung injury(ALI).Method:A total of 96 patients with pulmonary contusion complicated with ALI who admitted to Maoming People's Hospital from November 2022 to October 2024 were prospectively selected as the research objects,they were divided into the control group and the treatment group according to the random number table method,with 48 cases in each group.The control group was given conventional treatment,while the treatment group was given 3 d blood perfusion on the basis of conventional treatment.The ventilator use time,ICU hospitalization time,occurrence of acute respiratory distress syndrome(ARDS),inflammatory indexes[interleukin(IL)-1β,IL-6,IL-8,tumor necrosis factor-α(TNF-α)],lung function and disease severity[sequential organ failure score(SOFA)]before treatment and 7 d of treatment were recorded between two groups.Result:The ventilator use time and ICU hospitalization time in the treatment group were shorter than those in the control group,the differences were statistically significant(P<0.05);at 7 d of treatment,the SOFA scores and the levels of IL-1β,IL-6,IL-8 and TNF-α in two groups decreased,and those in the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05);at 7 d of treatment,the oxygenation index and lung compliance of two groups increased,and those in the treatment group were higher than those in the control group,the differences were statistically significant(P<0.05);there was no significant difference in the incidence of ARDS between two groups during treatment(P>0.05).Conclusion:Early blood perfusion is effective in the treatment of patients with pulmonary contusion complicated with ALI,which can effectively shorten treatment cycle,reduce severity of disease,reduce inflammatory response and improve lung function.