Effects of Budesonide and Formoterol Fumarate Combined with Thiotropium Bromide Aerosol Inhalation in Treatment of Chronic Obstructive Pulmonary Disease

LIN Chengbiao

doi:10.14033/j.cnki.cfmr.2025.16.010

Abstract：Objective:To explore the effects of Budesonide and Formoterol Fumarate Combined with Thiotropium Bromide aerosol inhalation in treatment of chronic obstructive pulmonary disease(COPD).Method:A total of 200 patients diagnosed with COPD admitted to Minhou County General Hospital from February 2022 to February 2024 were included.According to random number table method,the patients were divided into two groups,100 cases in each group.The control group was treated with conventional symptomatic treatment,and combined with Budesonide and Formoterol Fumarate aerosol inhalation,and the observation group was treated with Budesonide and Formoterol Fumarate combined with Thiotropium Bromide aerosol inhalation.Symptom control time,arterial blood gas index,respiratory mechanics index,lung function and serum inflammatory factors were compared between the two groups.Result:The control time of symptoms such as cough,sputum and wheezing in observation group were shorter than those in control group,and the differences were statistically significant(P<0.05).After treatment,the partial pressure of arterial blood oxygen(PaO2)of the two groups were increased,and the observation group was higher than the control group;the partial pressure of arterial blood carbon dioxide(PaCO2)of the two groups were decreased,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,total airway viscosity resistance at 5 Hz(R5)and central airway viscosity resistance at 20 Hz(R20)were decreased in two groups,and the indexes in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,forced vital capacity,peak expiratory flow rate and forced expiratory volume in one second of the two groups were increased,and the indexes in observation group were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,tumor necrosis factor-α(TNF-α),interleukin(IL-6)-6 and IL-8 were decreased in two groups,and the indexes in observation group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:The treatment of Budesonide and Formoterol Fumarate combined with Tiotropium Bromide aerosol inhalation in the treatment of patients with COPD can control the impact of symptoms in a shorter period of time,improve arterial blood gas and respiratory mechanics indicators,adjust lung function status and serum inflammatory factors,and meet clinical medication expectations.