Influencing Factors Analysis of Low Anterior Resection Syndrome in Patients with Rectal Cancer after Laparoscopic Radical Resection of Rectal Cancer
PENG Ziyun
FU Wenhong
CHEN Kang
YANG Wenzhi
Abstract：Objective:To investigate the influencing factors of low anterior resection syndrome(LARS)in patients with rectal cancer after laparoscopic radical resection of rectal cancer.Method:The clinical data of 104 patients with rectal cancer who underwent laparoscopic radical resection of rectal cancer in Kunming Traditional Chinese Medicine Hospital from June 2019 to August 2024 were collected,the incidence of LARS at 3 months after operation was counted,and the influencing factors of LARS were analyzed by univariate and multivariate logistic regression.Result:Among 104 patients with rectal cancer who underwent laparoscopic radical resection of rectal cancer were followed up for 3 months,the incidence of LARS was 59.62%(62/104).Univariate analysis showed that the proportion of body mass index≥24 kg/m2,history of hypertension,preoperative radiotherapy,anastomotic distance<5 cm and postoperative anastomotic leakage in the LARS group were higher than those in the non-LARS group,and the differences were statistically significant(P<0.05);there were no significant differences in gender,age,history of diabetes,tumor location,tumor diameter,histopathology,operation time,length of resected intestine,anastomosis method and first postoperative exhaust time between two groups(P>0.05).Multivariate logistic regression analysis showed that preoperative radiotherapy(OR=5.181,P<0.05),anastomotic distance<5 cm(OR=4.600,P<0.05),and postoperative anastomotic leakage(OR=4.963,P<0.05)were risk factors for LARS after laparoscopic radical resection of rectal cancer in patients with colorectal cancer.Conclusion:The incidence of LARS is relatively high in patients with rectal cancer after laparoscopic radical resection of rectal cancer,among which preoperative radiotherapy,anastomotic distance<5 cm and postoperative anastomotic leakage are the main influencing factors,targeted management strategies should be developed to reduce the risk of LARS.
Keywords：Rectal cancerLaparoscopic radical resection of rectal cancerLow anterior resection syndrome
Publication Date：2025-06-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 24-27 )