Effect of Flexible Ureteroscope Holmium Laser Lithotripsy in the Treatment of Renal Calculus

QING Nan

doi:10.14033/j.cnki.cfmr.2025.16.006

Abstract：Objective:To explore the effect of flexible ureteroscope holmium laser lithotripsy in renal calculus.Method:A total of 100 patients with renal calculus admitted to the Department of Urology of 922 Hospital of the Joint Service Logistics Support Force of the Chinese People's Liberation Army from November 2022 to July 2024 were selected for the study,they were randomly divided into two groups according to the random sampling method 1∶1,50 cases in each group.The percutaneous group was treated with percutaneous holmium laser lithotripsy,and the flexible ureteroscopy group was treated with flexible ureteroscope holmium laser lithotripsy.The one-time stone clearance,operation-related indicators,oxidative stress indicators,renal function indicators and complications were compared between two groups.Result:The one-time stone clearance rate of the flexible ureteroscopy group was higher than that of the percutaneous group,the operation time,catheter indwelling time and hospitalization time were shorter than those of the percutaneous group,and the intraoperative blood loss was less than that of the percutaneous group,the differences were statistically significant(P<0.05);the level of superoxide dismutase(SOD)in the flexible ureteroscopy group after operation was higher than that in the percutaneous group,and the levels of norepinephrine(NE),nitric oxide(NO),serum creatinine(Cr),urea nitrogen(BUN),β2-microglobulin(β2-MG)and kidney injury molecule-1(KIM-1)were lower than those in the percutaneous group,the differences were statistically significant(P<0.05);there was no significant difference in the incidence of complications between two groups(P>0.05).Conclusion:Flexible ureteroscope holmium laser lithotripsy has a good effect in the treatment of renal calculus,which can not only effectively improve the one-time stone clearance rate,but also reduce the oxidative stress function,and has a positive effect on protecting their renal function.