Effect of Elective CP after VPS in the Treatment of Patients with Traumatic Brain Injury Complicated with Hydrocephalus
LIU Wenqing
HUO Xianhao
XU Xingguo
ZHUANG Zhijie
KONG Lingge
Abstract：Objective:To investigate the effect of selective cranioplasty(CP)after ventriculoperitoneal shunt(VPS)in patients with traumatic brain injury complicated with hydrocephalus and its effect on serum levels of myelin basic protein(MBP),calcium binding protein S-100β(S-100β)and neuron-specific enolase(NSE).Method:A total of 98 patients with traumatic brain injury complicated with hydrocephalus who treated in General Hospital of Ningxia Medical University from March 2021 to April 2024 were selected,they were divided into the observation group(elective CP after VPS treatment,49 cases)and the control group(VPS and CP treatment at the same time,49 cases)according to the computer grouping method.The postoperative outcomes,serological indicators and complications were compared between two groups.Result:There were no significant differences in the postoperative ICU stay time and hospitalization days between two groups(P>0.05);before operation,there were no significant differences in Fugl-Meyer motor function assessment scale(FMAS)scores and Barthel index rating scale(BI)scores between two groups(P>0.05);at 3 months after operation,the FMAS scores and BI scores of two groups increased,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).At 7 d after operation,the levels of NSE,S-100β and MBP in two groups decreased,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between two groups(P>0.05).Conclusion:The selective CP after VPS in patients with traumatic brain injury complicated with hydrocephalus can promote postoperative outcome,reduce the levels of NSE,S-100β and MBP,and has good safety.
Keywords：CranioplastyVentriculoperitoneal shuntHydrocephalusTraumatic brain injuryNeuron specific enolaseMyelin basic protein
Publication Date：2025-06-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 17-20 )