Clinical Efficacy of Short-term Insulin Intensification Combined with Liraglutide in the Treatment of T2DM

LI Yu

doi:10.14033/j.cnki.cfmr.2025.16.004

Abstract：Objective:To analyse the clinical effectiveness of short-term insulin intensification combined with Liraglutide in the treatment of patients with type 2 diabetes mellitus(T2DM).Method:A total of 80 newly diagnosed T2DM patients admitted to Anshun People's Hospital from January 2022 to June 2024 were selected and divided into groups according to random number table method,with 40 patients in each group.The hypoglycemic regimen of control group was Liraglutide;the observation group was treated with Liraglutide combined with insulin short-term intensive treatment,and the blood glucose control effect and islet function were compared between the two groups.Result:The blood glucose relief rate of the observation group was 97.50%,which was higher than 80.00%of the control group,the time for blood glucose to reach the standard was shorter than that of the control group,and the differences were statistically significant(P<0.05).At 3 months after treatment,the blood glucose levels in the observation group were lower than those in the control group,insulin resistance(HOMA-IR)was lower than that in the control group,and insulin secretion index(HOMA-β)was higher than that in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the recurrence of hypoglycemia and hyperglycemia between the two treatment groups(P>0.05).Conclusion:The use of short-term intensive insulin combined with Liraglutide treatment for T2DM patients can improve the effect of glycaemic control,reduce the magnitude of glycaemic fluctuations and improve the patients'pancreatic islet function.