Efficacy of Corticosteroids Combined with Early Sequential Operfusion for Acute Bee Sting Rhabdomyolysis and Its Effect on Serum Levels of Inflammatory Factors

YU Xingsu; WANG Jian; LI Hui; XU Xinyan

doi:10.14033/j.cnki.cfmr.2025.12.018

Abstract：Objective:To investigate the efficacy of corticosteroids and early sequential blood perfusion(HP)for acute bee sting rhabdomyolysis(RM)and its effect on serum inflammatory factors.Method:90 patients with RM caused by acute bee sting treated in Renhuai People's Hospital from December 2018 to December 2023 were selected as research objects and divided into observation group and control group according to random number table method,with 45 cases in each group.The observation group was treated with glucocorticoid combined with early sequential HP,while the control group was treated with early sequential HP.Serum creatinine(SCr),blood urea nittogen(BUN)and uric acid(UA)levels,serum creatine kinase(CK)levels,myoglobin(Myo),interleukin-6(IL-6)and procalcitonin(PCT)levels of the two groups were detected before and 72 h after treatment,respectively,and the prognosis of the two groups was analyzed.Result:After treatment,the levels of SCr,BUN and UA in the two groups were reduced compared with those before treatment,and the levels in the observation group were lower,and the difference was statistically significant(P<0.05).After treatment,the levels of CK and Myo in the two groups were reduced compared with those before treatment,and the levels in the observation group were lower,and the difference was statistically significant(P<0.05).After treatment,the levels of IL-6 and PCT in both groups were reduced compared with those before treatment,and the levels in observation group were lower,and the difference was statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Glucocorticoids combined with early sequential HP can effectively reduce renal function injury in RM patients caused by acute bee sting,clear CK,Myo and other cell contents,reduce serum inflammatory factor levels,and improve patient prognosis.