Effect of High-frequency Oscillatory Ventilation under Capacity Guarantee in the Treatment of Neonatal Respiratory Distress Syndrome

XU Xiaozhe; XIE Xupei; YU Wuzhou

doi:10.14033/j.cnki.cfmr.2025.11.010

Abstract：Objective:To analyze the effect of high-frequency oscillatory ventilation under capacity guarantee in the treatment of neonatal respiratory distress syndrome.Method:A total of 96 children with neonatal respiratory distress syndrome who treated in Puning Maternal and Child Health and Family Planning Service Center from January 2023 to March 2024 were selected as the research objects,they were divided into the control group and the study group according to the random number table method,with 48 cases in each group.Both groups was given pulmonary surfactant supplementation after admission,the control group was given conventional mechanical ventilation,and the study group was given high-frequency oscillatory ventilation under capacity guarantee.The therapeutic effect,blood gas indexes[arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)],lung function[tidal volume(TV),peak volume ratio(VPEF/VE),peak time ratio(TPTEF/TE)]and the incidence of complications were compared between two groups.Result:The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05);after treatment,the blood gas indexes,inflammatory factor levels and lung function indexes of the study group were better than those of the control group,and the differences were statistically significant(P<0.05);there was no significant difference in the incidence of complications between two groups(P>0.05).Conclusion:The effect of high-frequency oscillatory ventilation under capacity guarantee in the treatment of neonatal respiratory distress syndrome a definite,which can improve blood gas indexes and lung function,reduce inflammatory factor levels,and reduce the risk of complications.