Value of NLR,LDH and DDR in Evaluation and Diagnosis of Mycoplasma Pneumoniae Necrotizing Pneumonia in Children

WU Wenbin; YOU Yuting; HUANG Xiaoqiang; HONG Wanqian; ZHENG Jingyang

doi:10.14033/j.cnki.cfmr.2025.09.016

Abstract：Objective:To analyze the application value of neutrophil to lymphocyte ratio(NLR),lactate dehydrogenase(LDH)and D-dimer(DDR)in evaluation and diagnosis of mycoplasma pneumoniae necrotizing pneumonia(MPNP)in children.Method:A total of 82mycoplasma pneumoniae pneumonia(MPP)children admitted to Quanzhou Maternal and Child Health Hospital and Children's Hospital from June 2022 to June 2024 were selected as the study objects.According to whether they developed necrotic pneumonia(NP),they were divided into MPNP group(39 cases)and non-MPNP group(43 cases).Baseline data and laboratory test results were compared between the two groups,and the influencing factors of MPNP in children with MPP were analyzed by logistic stepstep regression.The working characteristic curve of subjects was drawn,and the area under the curve(AUC)was used to evaluate the predictive efficacy of each influencing factor in MPNP in children with MPP.Result:There were significant differences in NLR,LDH and DDR levels between the two groups(P<0.05).logistic regression analysis showed that NLR,LDH and DDR levels were the influencing factors for MPNP in MPP children(P<0.05).The AUC predicted by NLR,LDH and DDR levels for MPNP in MPP children was 0.759,0.691 and 0.732,respectively.The AUC predicted by NLR,LDH and DDR levels was 0.858,which was higher than that by single detection,and the difference was statistically significant(P<0.001).The sensitivity and specificity of combined detection were 69.23%and 95.35%.Conclusion:NLR,LDH and DDR levels were significantly correlated with MPNP in children with MPP,and could be used as predictors of MPNP in children with MPP.Combined detection could improve the diagnostic accuracy.