Analysis of Expression of ER,PR,HER-2 and Ki-67 in Cancer Tissues of Overweight and Obese Female Breast Cancer Patients

LIANG Yajing; HAO Jincheng

doi:10.14033/j.cnki.cfmr.2025.08.015

Abstract：Objective:To analyze the expressions of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER-2)and cell proliferation marker Ki-67 antigen(Ki-67)in cancer tissues of overweight and obese female breast cancer patients.Method:The clinical data of 160 female breast cancer patients who treated in Rizhao Hospital of Traditional Chinese Medicine from May 2021 to December 2023 were retrospectively analyzed,the patients were grouped according to body mass index(BMI),83 patients with BMI≥24.0 kg/m2 were used as the study group,and 77 patients with 18.5 kg/m2≤BMI<24.0 kg/m2 were used as the control group.Immunohistochemical detection was performed on two groups of cancer tissues,the expressions of ER,PR,HER-2,Ki-67 and clinical features were compared between two groups.Result:Among 160 female breast cancer patients,the positive rates of ER,PR,HER-2 expression and high expression of Ki-67 were 76.88%(123/160),68.13%(109/160),26.88%(43/160)and 81.25%(130/160),respectively.There were no significant differences in the positive rate of PR,the positive rate of HER-2 and the high expression rate of Ki-67 between two groups(P>0.05);the positive rate of ER in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in age between two groups(P>0.05);however,the proportion of tumor diameter>5 cm invading skin or chest wall,TNM stage Ⅲ-Ⅳ,poor differentiation and lymph node metastasis in the study group were significantly higher than those in the control group,and the differences was statistically significant(P<0.05).Conclusion:The expression of ER is higher,tumor diameter is larger,TNM stage and pathological stage are higher,and lymph node metastasis rate is higher in overweight and obese female breast cancer patients.