Influencing Factors in T2DM Complicated with Hyperthyroidism and Diagnostic Efficacy of Serum GDF-15 Combined with NRG4

CHEN Li; XIA Yunya

doi:10.14033/j.cnki.cfmr.2025.08.014

Abstract：Objective:To study the influence factor of type 2 diabetes mellitus(T2DM)complicated with hyperthyroidism and the diagnostic efficacy of serum growth differentiation factor-15(GDF-15)combined with and neuregulin 4(NRG4).Method:A total of 120 T2DM patients admitted to Gaoyou People's Hospital from March 2021 to March 2023 were studied.They were divided into hyperthyroidism group(n=35)and non-hyperthyroidism group(n=85)according to whether complicated with hyperthyroidism.Baseline data and laboratory indicators were compared between the two groups.The influencing factors of T2DM complicated with hyperthyroidism were determined by multivariate logistic regression analysis.Receiver operating characteristic(ROC)curve was also used to determine the efficacy of serum GDF-15 and NRG4 levels in diagnosing T2DM complicated with Hyperthyroidism patients.Result:Fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),homeostasis model assessment of insulin resistance index(HOMA-IR),free triiodothyronine(FT3),free tetraiodothyronine(FT4),GDF-15 and NRG4 in hyperthyroidism group were higher than those in non-hyperthyroidism group,the level of thyroid stimulating hormone(TSH)was lower than that of non-hyperthyroidism group,and the differences were statistically significant(P<0.05).There were no significant differences in gender,age,body mass index(BMI),smoking and drinking situation between the two groups(P>0.05).Multivariate logistic regression analysis confirmed that the influencing factors ofT2DM complicated with hyperthyroidism patients included FBG,HbA1c,HOMA-IR,FT3,FT4,TSH,GDF-15 and NRG4(P<0.05).ROC curve analysis confirmed that the area under the curve of GDF-15 and NRG4 combined to predict T2DM complicated with hyperthyroidism was 0.846,higher than 0.768 and 0.775 of individual detection.Conclusion:The influencing factors of T2DM complicated with hyperthyroidism patients are FBG,HbA1c,HOMA-IR,FT3,FT4,TSH,GDF-15 and NRG4,and the combined detection of GDF-15 and NRG4 can effectively diagnose T2DM complicated with hyperthyroidism.