Effect of Doxofylline Combined with Budesonide in the Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease
YU Luan
Abstract：Objective:To explore the effect of Doxofylline combined with Budesonide in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD).Method:A total of 100 elderly patients with COPD who admitted to Liupanshui People's Hospital from January to December 2023 were selected as the research objects,they were divided into the observation group(n=50,Doxofylline combined with Budesonide treatment)and the control group(n=50,Budesonide treatment)according to the random number table method.The lung function[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),peak expiratory flow(PEF)],blood gas indexes[oxygen saturation(SaO2),partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2)],respiratory mechanics indexes[dynamic lung compliance(Cdyn),peak airway pressure(PIP),airway resistance(Raw)],quality of life and adverse reactions were compared between two groups.Result:The FEV1,FVC,PEF,SaO2,PaO2,Cdyn and generic quality of life inventory-74(GQOLI-74)scores of the observation group after treatment were higher than those of the control group,and PaCO2,Raw and PIP were lower than those of the control group,the differences were statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Doxofylline combined with Budesonide in the treatment of elderly patients with COPD can improve lung function,regulate blood gas indexes,improve respiratory mechanics indexes and quality of life,with few adverse reactions.
Keywords：Chronic obstructive pulmonary diseaseDoxofyllineBudesonideLung function
Publication Date：2025-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 50-53 )