Effect of Traditional Chinese Medicine Bigeminal Therapy Combined with Ornidazole Suppository in the Treatment of Elderly Patients with Vaginitis of Liver and Kidney Yin Deficiency Type

ZHAO Mei; ZHOU Fuhua; HU Xiumei; XIE Caiping; WU Guoming; CHEN Danlin

doi:10.14033/j.cnki.cfmr.2025.06.014

Abstract：Objective:To investigate the effect of Traditional Chinese Medicine bigeminal therapy combined with ornidazole suppository in the treatment of elderly patients with vaginitis of liver and kidney Yin deficiency type.Method:A total of 80 patients with senile vaginitis of liver and kidney Yin deficiency type admitted to Sanming Integrated Medicine Hospital from May 2022 to May 2024 were selected as the study objects divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with ornidazole suppository.On the basis of the control group,the observation group was given Zishen Qushi decoction and compound snake seed powder fumigation.The total effective rate of treatment for vaginitis,TCM symptom score before and after treatment,pH value,inflammatory indexes of vaginal secretions[interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]and immune defense factors[human β-defensin-1(HBD-1),human β-defensin-2(HBD-2),human beta-defensin 3(HBD-3)and human beta-defensin 5(HBD-5)],were compared between the two groups.Result:The total effective rate of vaginitis treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in TCM syndrome score,pH value,inflammation index of vaginal secretions and immune defense factors between the two groups before treatment(P>0.05).After 1 course of treatment and 2 courses of treatment,the scores of TCM symptoms,pH value,inflammatory indexes of vaginal secretions and immune defense factors in the observation group were significantly lower than those in the control group,with statistical significance(P<0.05).Conclusion:The combination of TCM and Ornidazole suppository in the treatment of senile vaginitis with liver and kidney Yin deficiency has good curative effect,and can significantly improve the local inflammation and immune defense status of patients.