Clinical Effect of Escitalopram Combined with Moderate Intensity Aerobic Exercise in the Treatment of Mild to Moderate Depression

LI Xianyang; JIN Yong

doi:10.14033/j.cnki.cfmr.2025.02.015

Abstract：Objective:To explore the clinical effect of Escitalopram combined with moderate intensity aerobic exercise in the treatment of mild to moderate depression.Method:From January to December 2023,70 patients with mild to moderate depression who treated in Yichang Special Care Hospital were selected as the study subjects,the enrolled patients were divided into the control group(35 cases)and the observation group(35 cases).The control group was treated with Escitalopram,while the observation group was treated with Escitalopram combined with moderate intensity aerobic exercise.The clinical efficacy,Hamilton depression rating scale(HAMD-24)score,coping style score,and biochemical indicators[5-hydroxytryptamine(5-HT),norepinephrine(NE)]levels between two groups were compared.Result:Compared with the control group(77.1％),the observation group(94.3％)had a significantly higher total effective rate of treatment and the difference was statistically significant(P＜0.05);after treatment,1 month after treatment and 2 months after treatment,the HAMD-24 scores of two groups were decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P＜0.05);after treatment,the positive coping scores,5-HT and NE levels of two groups were increased,and the negative coping scores were decreased,the positive coping scores,5-HT and NE levels of the observation group were higher than those of the control group,and the negative coping score was lower than that of the control group,the differences were statistically significant(P＜0.05).Conclusion:Compared with Escitalopram monotherapy,Escitalopram combined with moderate intensity aerobic exercise in the treatment of mild to moderate depression has a more significant effect,which helps alleviate depressive symptoms,the mechanism may be related to improving 5-HT and NE levels.