Effect of Budesonide Combined with Qingjin Huatan Decoction in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Phlegm Heat Obstructing Lung Syndrome

XUE Yuhui; JIANG Baihua

doi:10.14033/j.cnki.cfmr.2025.02.014

Abstract：Objective:To explore the effect of Budesonide combined with Qingjin Huatan Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease with phlegm heat obstructing lung syndrome.Method:A total of 86 patients with acute exacerbation of chronic obstructive pulmonary disease with phlegm heat obstructing lung syndrome who treated in Heilongjiang Academy of Traditional Chinese Medicine from January 2022 to December 2023 were selected as the study objects,they were divided into the control group and the experimental group by random number table method,with 43 cases in each group.The control group was treated with Budesonide,and the experimental group was treated with Budesonide combined with Qingjin Huatan Decoction,the traditional Chinese medicine symptom scores,airway remodeling media[matrix metalloproteinase-9(MMP-9),tissue inhibitors of metalloproteinase-1(TIMP-1),transforming growth factor-β1(TGF-β1)],lung function[peak expiratory flow(PEF),forced expiratory volume in one second(FEV1)and forced vital capacity(FVC)ratio(FEV1/FVC)],therapeutic effects and adverse reactions were compared between two groups.Result:After treatment,the symptom scores,MMP-9,TIMP-1 and TGF-β1 levels in two groups were decreased,and those in the experimental group were lower than the control group,the differences were statistically significant(P＜0.05);after treatment,the PEF and FEV1/FVC in two groups were increased,and those in the experimental group were higher than the control group,the differences were statistically significant(P＜0.05);the total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P＜0.05);there was no significant difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Budesonide aerosol inhalation combined with Qingjin Huatan Decoction oral in the treatment of acute exacerbation of chronic obstructive pulmonary disease with phlegm heat obstructing lung syndrome can inhibit airway remodeling,improve lung function,reduce clinical symptoms,and has high safety.