Effect of Leuprelin Acetate Microspheres for Injection Combined with Laparoscopic Surgery on Patients with Endometriosis

TIAN Xing

doi:10.14033/j.cnki.cfmr.2025.02.005

Abstract：Objective:To explore the effect of Leuprelin Acetate Microspheres for Injection combined with laparoscopic surgery on patients with endometriosis(EMS).Method:A total of 86 EMS patients admitted to Beijing Huairou Hospital from January 2021 to September 2023 were selected.They were divided into study group(n=43)and control group(n=43)according to random number table method.Both groups received laparoscopic surgery.The control group was given Desogestrel and Ethinylestradiol Tablets,and the study group was given Leuprelin Acetate Microspheres for Injection.The clinical efficacy,serological indexes,ovarian function,pain degree before and after treatment,adverse reactions were compared between the two groups.Result:The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of matrix protease-2(MMP-2)and vascular endothelial growth factor(VEGF)were decreased in both groups,and the levels of MMP-2 and VEGF in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the number of follicles in the central ovarian sinus decreased and the ovarian volume decreased in the two groups,the number of sinus follicle in the ovarian in the study group was more than that in the control group,and the ovarian volume was greater than that in the control group,and the differences were statistically significant(P＜0.05).After treatment,the visual analogue scale(VAS)scores of dysmenorrhea and coital pain were decreased in both groups,and the VAS scores of dysmenorrhea and coital pain in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:The application of Leuprelin Acetate Microspheres for Injection combined with laparoscopic surgery in EMS patients can improve clinical efficacy,improve serological indexes,ovarian function,reduce pain degree,and have high safety.