Application of Platelet Parameters and Inflammatory Markers in the Early Diagnosis of Gram-negative Bacterial Bloodstream Infections

ZHAO Danmei

doi:10.14033/j.cnki.cfmr.2025.01.018

Abstract：Objective:To explore the role of platelet parameters and inflammation factor indexes in the early diagnosis of Gram-negative (GN) bacterial bloodstream infections. Method:A total of 59 patients with bloodstream infection diagnosed and treated in Nanjing Gaochun People's Hospital from June to September 2023 were selected as the experimental group. There were 37 cases of GN infection (GN group) and 22 cases of Gram positive (GP) infection (GP group). Twenty healthy patients were selected as the control group. Platelet parameters[platelet count (PLT),platelet accumulation (PCT),platelet distribution width (PDW),mean platelet volume (MPV)]and inflammatory factors[interleukin-6 (IL-6),C-reactive protein (CRP)]of the three groups were statistically compared. The diagnostic value of platelet parameters and inflammatory indexes for GN bacteria was analyzed. Result:PCT,PDW and MPV in GP group and GN group were significantly higher than those in control group,and GN group was higher than GP group,the differences were statistically significant (P<0.05). The PLT of GN group and GP group were lower than that of control group,and the PLT of GN group was lower than that of GP group,the differences were statistically significant (P<0.05). The levels of IL-6 and CRP in GP group and GN group were higher than those in control group,the IL-6 level in GN group was lower than that in GP group,and the CRP level was higher than that in GP group,the differences were statistically significant (P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the AUC values of PLT,PCT,PDW,MPV,IL-6 and CRP for diagnosis GN infection were 0.676,0.754,0.585,0.590,0.622 and 0.665,respectively,while the AUC value of combined examination was the highest,which was 0.923 (P<0.05). Conclusion:The combined examination of platelet parameters and inflammatory markers holds significant diagnostic value in detecting Gram-negative bacterial bloodstream infections.