Effect of Cetylpyridinium Chloride Gargle Combined with Metronidazole on Patients with Gingivitis

TAN Li

doi:10.14033/j.cnki.cfmr.2025.01.015

Abstract：Objective:To investigate the effect of Cetylpyridinium Chloride Gargle combined with Metronidazole on patients with gingivitis. Method:A total of 126 patients with gingivitis treated in Qianxinan Prefecture Hospital of Traditional Chinese Medicine from July 2020 to May 2023 were selected. They were divided into control group and observation group according to random number table method,with 63 cases in each group. The control group was treated with Metronidazole Lozenges,and the observation group was treated with Cilpyridinium Chloride Gargle based on the control group. The clinical efficacy,oral health,pain degree,inflammation indexes,quality of life before and after treatment and adverse reactions were compared between the two groups. Result:The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05). After treatment,the scores of oral health impact profile (OHIP-14) and visual analogue scale (VAS) were decreased in both groups,and the scores of OHIP-14 and VAS were lower than those of the control group,the differences were statistically significant (P<0.05). After treatment,white blood cell count (WBC),absolute values of neutrophils and lymphocytes were decreased in both groups,and WBC,absolute values of neutrophils and lymphocytes in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05). After treatment,the scores of physiological,environmental,psychological and social relations in both groups were increased,and the scores of physiological,environmental,psychological and social relations in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion:In patients with gingivitis,the application of Cilpyridinium Chloride Gargle combined with Metronidazole has a definite effect,which can significantly improve the oral health of patients,relieve pain,reduce gum inflammation,and help improve the quality of life of patients with good safety.