Impact of Levosimendan Combined with Non-invasive Ventilator on Cardiac Function and Blood Gas Parameters in Patients with Acute Left Heart Failure

PAN Zilei; ZHANG Ling; SHA Weiwei; TENG Tianqi

doi:10.14033/j.cnki.cfmr.2025.01.012

Abstract：Objective:To analyze the impact of Levosimendan combined with non-invasive ventilator on cardiac function and blood gas parameters in patients with acute left heart failure (ALHF). Method:A total of 102 patients with ALHF admitted to Xuzhou Cancer Hospital from February 2020 to December 2023 were retrospectively selected. According to different treatment methods,the patients were divided combined group and conventional group,51 cases in each group. The conventional group was given high flow nasal catheter oxygen,and the combined group was given Levosimendan combined with non-invasive ventilator treatment. The clinical efficacy,cardiac function index and blood gas index before treatment and after 7 d of treatment were compared between the two groups. Result:The total effective rate of the combined group was 92.16％ after 7 d of treatment,which was higher than 76.47％ of the conventional group,and the difference was statistically significant (P<0.05). After 7 d of treatment,the NT-terminal brain natriuretic peptide precursor (NT-proBNP) and left ventricular end-diastolic inner diameter (LVEDD) of both groups were decreased,and left ventricular ejection fraction (LVEF) was increased,the NT-proBNP and LVEDD of the combined group were lower than those of the conventional group,and LVEF was higher than that of the conventional group,and the difference was statistically significant (P<0.05). After 7 d of treatment,the partial pressure of carbon dioxide (PaCO2) decreased in both groups,while arterial oxygen partial pressure (PaO2) and pulse oxygen saturation (SpO2) increased,PaO2 and SpO2 in the combined group were higher than those in the conventional group,and PaCO2 was lower than that in the conventional group,the differences were statistically significant (P<0.05). Conclusion:Levosimendan combined with non-invasive ventilator can effectively improve cardiac ejection function and optimize blood gas index in patients with ALHF.