Effect of Metformin Combined with Dapagliflozin on Diabetic Nephropathy Patients

LIN Weixiang

doi:10.14033/j.cnki.cfmr.2024.34.011

Abstract：Objective:To investigate the effect of Metformin combined with Dapagliflozin on diabetic nephropathy patients.Method:A total of 120 diabetic nephropathy patients admitted to the Seventh People's Hospital of Panyu District,Guangzhou City from January 2022 to January 2024 were selected as the study objects.They were divided into observation group and control group according to random number table method,with 60 cases in each group.The control group was treated with Metformin,and the observation group was treated with Dapagliflozin on the basis of the control group.Blood glucose indexes,renal function indexes,blood pressure indexes before and after treatment and adverse cardiovascular events were compared between the two groups.Result:After treatment,glycosylated hemoglobin(HbA1c),fasting blood glucose(FPG)and 2 h postprandial blood glucose(2 h PG)in both groups were decreased,and HbA1c,FPG and 2 h PG in observation group were lower than those in control group,the differences were statistically significant(P<0.05).The incidence of adverse cardiovascular events in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).After treatment,blood urea nitrogen(BUN),blood creatinine(Scr),urinary albumin/creatinine ratio(UACR)and 24 h urinary microalbumin in the two groups were lower than those before treatment,and BUN,Scr,UACR and 24 h urinary microalbumin in observation group were lower than control group,the differences were statistically significant(P<0.05).After treatment,the systolic blood pressure and diastolic blood pressure of the two groups were lower than those before treatment,and the systolic blood pressure and diastolic blood pressure of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:Metformin combined with Dapagliflozin can play a role in protecting human kidney and cardiovascular function,and the safety is high.