Significance of Urinary α1 Microglobulin(α1-MG),Urinary β2 Microglobulin(β2-MG)and Urinary Microalbumin/Creatinine Ratio(ACR)Combined Detection in Early Diagnosis of Diabetic Nephropathy/
ZHOU Yue
LI Ying
TAO Yunjuan
ZHAO Qihao
ZHU Yong
Abstract：Objective:To investigate the significance of urinary α1 microglobulin(α1-MG),urinary β2 microglobulin(β2-MG)and urinary microalbumin/creatinine ratio(ACR)combined detection in early-stage diabetic nephropathy(EDN).Method:A total of 208 patients with type 2 diabetes who were hospitalized in Yancheng Hospital of Traditional Chinese Medicine from November 2022 to December 2023 were selected as the study objects.According to the 24-hour urinary albumin ejection rate(UAER),the patients were divided into diabetes mellitus(DM)group,EDN group and clinical diabetic nephropathy(DN)group.These three groups are study groups.Another 43 healthy subjects in Yancheng Hospital of Traditional Chinese Medicine were selected as control group.The differences in urine α1-MG,β2-MG and ACR detection results between the two groups were compared,and the differences in urine α1-MG,β2-MG and ACR detection results between the study group were compared,and receiver operating curve(ROC)was drawn to analyze the diagnostic significance of 3 indicators alone and combined detection in early kidney injury in diabetic patients.Result:Urinary α1-MG,β2-MG and ACR levels in study group were higher than those in control group,urinary α1-MG,β2-MG and ACR levels in EDN group were significantly higher than those in DM group,and the three indexes in DN group were significantly higher than those in EDN group,and the differences were statistically significant(P＜0.05).ROC curve showed that the AUC of α1-MG,β2-MG and ACR alone and combined detection in predicting early kidney injury in type 2 diabetes mellitus were 0.833,0.870,0.981 and 0.993,respectively,and the combined detection had a higher predictive value(P＜0.05).Conclusion:Urine α1-MG,β2-MG and ACR combined detection has high clinical value in early diagnosis of diabetic nephropathy.
Keywords：Early-stage diabetic nephropathyUrinary α1-MGUrinary β2-MGUrinary ACR
Publication Date：2024-11-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 28-31 )