Analysis of Coagulation Function Changes and Risk Factors for Hypercoagulability in Patients with Chronic Kidney Disease in Stages 3-5

QIU Sujuan; CHEN Wenqing

doi:10.14033/j.cnki.cfmr.2024.32.020

Abstract：Objective:To analyze the coagulation function changes and risk factors for hypercoagulability in patients with chronic kidney disease(CKD)in stages 3-5.Method:A total of 105 CKD stage 3-5 patients admitted to the First Hospital of Xiamen University from January 2019 to January 2024 were selected as the CKD group,and 55 healthy volunteers who underwent physical examinations during the same period were selected as the control group.The general information of CKD group was collected.Laboratory indicators of two groups were detected.CKD group was divided into groups.The grouping situation was analyzed and the prothrombin time(PT),thromboplastin time(APTT),thrombin time(TT),and fibrinogen(FIB)of the three groups was compared.The general information and laboratory indicators between the high coagulation state group and the non high coagulation state group was compared.The risk factors for hypercoagulability in CKD stage 3-5 patients was analyzed.Result:There were 40 cases in the CKD hypercoagulable state group and 65 cases in the CKD non hypercoagulable state group.The PT,APTT,and TT in the CKD hypercoagulable state group were shorter than those in the CKD non hypercoagulable state group and the control group,and the FIB level was higher than that in the CKD non hypercoagulable state group and the control group,the PT,APTT,and TT in the CKD non hypercoagulable state group were shorter than those in the control group,and the FIB level was higher than that in the control group,the differences were statistically significant(P＜0.05).The levels of creatinine(Scr)and C-reactive protein(CRP)in the CKD hypercoagulable state group were higher than those in the CKD non hypercoagulable state group,the estimated glomerular filtration rate(eGFR)and hemoglobin(Hb)levels were lower than those in the CKD non hypercoagulable state group,and the differences were statistically significant(P＜0.05).CRP was the risk factor for hypercoagulability in CKD stage 3-5 patients,while eGFR and Hb were protective factors for hypercoagulability in CKD stage 3-5 patients(P＜0.05).Conclusion:CKD stage 3-5 patients have coagulation dysfunction,and eGFR,CRP,and Hb levels are factors that affect patients'hypercoagulability.Clinical monitoring of these indicators should be strengthened to prevent the occurrence of hypercoagulability.