Diagnostic Value of Negative Ultrasound Cyst Bud Difference and Serum hCG,E2,P,and CA125 Levels for Early Threatened Miscarriage
YUAN Xinhua
Abstract：Objective:To explore the diagnostic value of negative ultrasound cyst bud difference and serum levels of human chorionic gonadotropin(hCG),estradiol(E2),progesterone(P),and carbohydrate antigen 125(CA125)in early threatened miscarriage(ETA).Method:A total of 63 ETA patients from March 2023 to February 2024 who were admitted in the Second People's Hospital of Beihai were selected as the ETA group,and 45 normal pregnant women who were underwent prenatal check up during the same period were selected as the normal pregnancy group.All subjects were underwent transvaginal color Doppler ultrasound examination and serum hCG,E2,P,and CA125 detection.The differences in cyst bud difference and serum indicator levels in both groups were compared,and univariate and multivariate logistic regression analyses were performed.The diagnostic value was evaluated by receiver operating characteristic(ROC)curves.Result:In comparision of the normal pregnancy group,the abnormal rate of cyst bud difference in the ETA group was higher,and the difference was statistically significant(P＜0.05).In comparision of the normal pregnancy group,cyst bud difference,hCG,E2,and P levels in the ETA group were lower,and CA125 levels were higher,cyst bud difference was larger,the differences were statistically significant(P＜0.05).The results of multivariate logistic regression analysis showed that cyst bud difference(OR=1.885),and CA125(OR=1.893)were independent risk factors affecting the occurrence of ETA(P＜0.05),hCG(OR=0.713),E2(OR=0.629),P(OR=0.675)were protective factors(P＜0.05).The ROC curve was plotted,and the area under the curve(AUC)for ETA,including cyst bud difference,hCG,E2,P,CA125,and 5 indicators combined diagnosis were 0.765,0.737,0.670,0.628,0.592,and 0.881,respectively(P＜0.05).Conclusion:Cyst bud difference,hCG,E2,P,and CA125 can all be used to predict ETA.Abnormal cyst bud difference detected by negative ultrasound is of great significance for diagnosing ETA,and the combined diagnostic value is higher.It can provide reliable basis for subsequent treatment and improve pregnancy success rate.
Keywords：Early threatened miscarriageTransvaginal color Doppler ultrasound examinationCyst bud differenceHuman chorionic gonadotropinEstradiolProgesteroneCarbohydrate antigen 125
Publication Date：2024-11-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 74-79 )