Clinical Effect of Nasal High-flow Oxygen Inhalation Combined with Fiberoptic Bronchoscopy Lavage in the Adjuvant Treatment of Elderly Patients with Severe Pneumonia

LIN Jinxia; ZHANG Meiquan; HUANG Yingxiang

doi:10.14033/j.cnki.cfmr.2024.32.007

Abstract：Objective:To evaluate the clinical effect of nasal high-flow oxygen inhalation combined with fiberoptic bronchoscopy lavage in the adjuvant treatment of elderly patients with severe pneumonia.Method:A total of 98 elderly patients with severe pneumonia who hospitalized in the Department of Respiratory and Critical Care Medicine of Fujian Provincial Geriatric Hospital from September 2021 to September 2023 were selected as the research objects,the patients were divided into the control group(n=49)and the observation group(n=49)according to the random number table method.Two groups were given routine treatment+nasal high-flow oxygen inhalation intervention,and the observation group was combined fiberoptic bronchoscopy lavage adjuvant treatment.The blood gas indexes[carbon dioxide partial pressure(PaCO2),arterial oxygen partial pressure(PaO2),blood oxygen saturation(SaO2),oxygenation index(OI)],inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)],lung function[forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF),maximal mid-expiratory flow(MEF)]and mortality were compared between two groups.Result:The PaCO2,IL-6,IL-8 and TNF-α in the observation group after treatment,were lower than those in the control group,the PaO2,SaO2,OI,FEV1,FVC,PEF and MEF were higher than those in the control group,and the differences were statistically significant(P＜0.05);the mortality rate of the observation group within 3 months of treatment was lower than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion:Nasal high-flow oxygen inhalation combined with fiberoptic bronchoscopy lavage in the adjuvant treatment of elderly patients with severe pneumonia can improve blood gas index,lung function and inflammatory factor levels,and reduce mortality.