Effect of Recombinant Human Follicle-stimulating Hormone Combined with Chorionic Gonadotropin in the Treatment of Patients with Ovulation Disorder Infertility

SHI Huanhuan; BIAN Ruimin; ZHANG Caixia; ZHOU Yanli; GAO Junling; LI Na

doi:10.14033/j.cnki.cfmr.2024.31.010

Abstract：Objective:To study the effect of Recombinant Human Follicle-stimulating Hormone combined with Chorionic Gonadotropin in the treatment of patients with ovulation disorder infertility (ODI).Method:A total of 100 patients with ODI who admitted to Binzhou Medical University Affiliated Hospital from July 2020 to July 2023 were selected as the research objects,they were randomly divided into the combined group (n=50) and the reference group (n=50) by computer number single and double digital method.The reference group was treated with intramuscular injection of Chorionic Gonadotropin,and the combined group was treated with Recombinant Human Follicle-stimulating Hormone injection on the basis of the reference group.The diameter of dominant follicles and number of mature follicles,endocrine indexes[follicle-stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E2),progesterone (P)]levels,successful ovulation rate,pregnancy rate,ovarian hemodynamics[pulsation index (PI),resistance index (RI) and peak systolic velocity (PSV)]were compared between two groups.Result:After treatment,the diameter of dominant follicles,the number of mature follicles and the levels of FSH,LH,E2,P,PI and PSV in two groups were higher than those before treatment,and those in the combined group were higher than those in the reference group,the RI of two groups were lower than those before treatment,and that in the combined group was lower than that in the reference group,the differences were statistically significant (P<0.05);the successful ovulation rate and pregnancy rate of the combined group were higher than those of the reference group,and the difference was statistically significant (P<0.05).Conclusion:The combination of Recombinant Human Follicle-stimulating Hormone and Chorionic Gonadotropin can improve the ovarian function of patients with ODI,improve the levels of endocrine indicators,and increase the ovulation rate and pregnancy rate.