Application Value of Hyperbaric Oxygen Combined with Interventional Embolization in Patients with Intracranial Aneurysm and Its Effect on Nerve Function and Inflammatory Response
LI Wei
ZHONG Jun
FAN Yiguo
YANG Zhenggang
XIE Chao
Abstract：Objective:To analyze the application value of hyperbaric oxygen combined with interventional embolization in patients with intracranial aneurysm and its effect on nerve function and inflammatory response.Method:A total of 80 patients with intracranial aneurysm who admitted to the Neurosurgery Department of Songzi City People's Hospital from January 2022 to September 2023 were selected as the study objects,they were randomly divided into the control group and the study group,40 cases in each group.The control group was treated with interventional embolization,and the study group was treated with hyperbaric oxygen combined with interventional embolization.The middle cerebral artery,matrix metalloproteinase 9(MMP-9),cystatin C(Cys C),inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-10(IL-10)],neurological function[National Institute of Health stroke scale(NIHSS)],daily living ability[Barthel index(BI)],complications and clinical efficacy were compared between two groups.Result:Compared with the control group,the middle cerebral artery flow rate,cerebro vascular spasm(CVS),MMP-9,Cys C,IL-6,TNF-α levels and NIHSS scores in the study group after treatment were lower,and the BI score and IL-10 level were higher,the differences were statistically significant(P<0.05).Compared with the control group,the incidence of complications in the study group was lower,and the total treatment effective rate of treatment was higher,the differences were statistically significant(P<0.05).Conclusion:The combination of hyperbaric oxygen and interventional embolization can significantly improve the nerve function of patients with intracranial aneurysm,inhibit the level of inflammatory factors,reduce complications,improve clinical efficacy,and promote patients recovery.
Keywords：Intracranial aneurysmHyperbaric oxygenInterventional embolizationNerve functionInflammatory response
Publication Date：2024-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 18-22 )