Value of Colposcopy Examination,HR-HPV Examination,p16 Examination in Cervical Cancer Screening

GAO Shuqi; XIE Xiaomin; LIN Minghua

doi:10.14033/j.cnki.cfmr.2023.36.017

Abstract：Objective:To analyze the value of colposcopy examination,high-risk human papilloma virus(HR-HPV)examination,p16 examination in cervical cancer(CC)screening.Method:The clinical data of 218 patients with CC screening admitted to Pathology Department of Xiamen Fifth Hospital from December 2019 to December 2022 were retrospectively analyzed.All patients underwent colposcopy examination,HR-HPV examination,p16 examination,and pathological examination.Using pathological results as the gold standard,the results of pathological examination were counted.The results of colposcopy examination,HR-HPV examination,p16 examination alone and combination were analyzed.The consistency of the three methods and their combination with pathological examination was analyzed.The value of colposcopy examination,HR-HPV examination and p16 examination in CC screening was analyzed.Result:Pathological results showed that 90 cases(41.28％)of the 218 patients were normal/inflammatory,63 cases(28.90％)of cervical intraepithelial neoplasia Ⅰ(CINⅠ),53 cases(24.31％)of cervical intraepithelial neoplasia Ⅱ(CINⅡ)and cervical intraepithelial neoplasia Ⅲ(CINⅢ),and 12 cases(5.50％)of CC.The positive rates of colposcopy examination,HR-HPV examination,p16 examination and combination examination were 53.67％,58.26％,57.34％and 58.72％respectively.The Kappa values of colposcopy examination,HR-HPV examination,p16 examination and combination and pathological examination were 0.619,0.821,0.878 and 0.962 respectively(P<0.001),and the combination Kappa values were higher than those of other methods.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of the combination were higher than those of the three methods alone,the differences were statistically significant(P<0.05).Conclusion:The combination of p16 examination,HR-HPV examination and colposcopy examination has higher application value in CC screening.