Application Value of Joint Detection of Serum CA125,AFP,CA19-9 and CEA in the Diagnosis of Early Cervical Cancer

JIA Dongqing; FENG Hui; LI Zhenqi

doi:10.14033/j.cnki.cfmr.2023.36.015

Abstract：Objective:To analyze the application value of joint detection of serum carbohydrate antigen 125(CA125),alpha-fetoprotein(AFP),carbohydrate antigen 19-9(CA19-9)and carcinoembryonic antigen(CEA)in the diagnosis of early cervical cancer.Method:A total of 200 patients with early cervical cancer(group A)and 200 patients with cervical intraepithelial neoplasia(group B)who were admitted to Shan County Central Hospital from June 2015 to June 2020,and 200 healthy women(group C)who received routine physical examinations in the hospital during the same period were selected as the study subjects.Serum levels of CA125,AFP,CA19-9 and CEA were compared among the three groups.The serum indexes of different clinical stages and pathological types of early cervical cancer were compared.logistic regression was used to analyze the influencing factors of early cervical cancer.The diagnostic value of serum CA125,AFP,CA19-9 and CEA combined detection in early cervical cancer were analyzed.Result:The serum levels of CA125,AFP,CA19-9 and CEA in group A and group B were significantly higher than those in group C,and the serum levels of CA125,AFP,CA19-9 and CEA in group A were significantly higher than those in group B,the differences were statistically significant(P<0.05).Serum levels of CA125,AFP,CA19-9 and CEA in cervical cancer patients with stage Ⅰb and stage Ⅱa were significantly higher than those in stage Ⅰa,those in stage Ⅱa were significantly higher than those in stage Ⅰb,and those in adenocarcinoma and adenosquamous carcinoma were significantly higher than those in squamous carcinoma,the differences were statistically significant(P<0.05).The area under the curve(AUC)value of single serum CA19-9 in the diagnosis of early cervical cancer was the highest,with 38.85 U/mL cut-off,and the diagnostic sensitivity and specificity were 71.00％and 85.50％,respectively.Combined diagnosis AUC was 0.949,diagnostic sensitivity and specificity were 88.50％and 89.25％,respectively.Conclusion:All of serum CA125,AFP,CA19-9 and CEA can be used to diagnose early cervical cancer.Among them,CA19-9 can achieve the best performance in diagnosis with single index,joint detection of these indicators may further enhance the diagnostic performance.