Expression of MiR-26b in Preeclampsia Placenta and Its Correlation with Angiogenesis,Cell Invasion

FAN Xiaoping; ZENG Huaxia

doi:10.14033/j.cnki.cfmr.2023.36.014

Abstract：Objective:To investigate the expression of MiR-26b in preeclampsia placenta and its correlation with angiogenesis,cell invasion.Method:A total of 130 pregnant women with preeclampsia who gave birth in Zhongshan Torch Development Zone People's Hospital from January to December 2022 were selected as preeclampsia group,the pregnant women were divided into the mild preeclampsia group(n=97)and the severe preeclampsia group(n=33)according to the severity of the disease;fifty healthy pregnant women who gave birth in our hospital during the same period were selected as the normal control group.The differences of MiR-26b expression,angiogenesis and cell invasion related expression in placental tissues of three groups were compared,and the correlation between MiR-26b expression in placental tissues of preeclampsia women and angiogenesis and cell invasion were analyzed.Result:The expressions of miR-26b in placental tissue of the mild preeclampsia group and the severe preeclampsia group were higher than that of the normal control group,the mRNA expression levels of leukemia inhibitory factor(LIF),vascular endothelial growth factor(VEGF),matrix metallo-proteinase 9(MMP-9),placental growth factor(PLGF),acetate kinase 1(ACK1),homeobox protein B3(HOXB3),chromatin SWI/SNF-related matrix-associated actin-dependent regulatory factor subfamily A5(SMARCA5)and laminin α4(LAMA4)were lower than those in the normal control group,and the expression levels of the above indicators in placental tissue of the severe preeclampsia group had a greater variation,the differences were statistically significant(P<0.001).The expression of MiR-26b in placenta tissue of preeclampsia were negatively correlated with the expression of genes related to angiogenesis and cell invasion(P<0.05).Conclusion:The abnormally high expression of MiR-26b in placenta of preeclampsia may participate in the progression of the disease by inhibiting the expression of genes related to angiogenesis and cell invasion.