Effect of Esmolol Combined with Early Goal Directed Therapy on Septic Cardiomyopathy Patients

ZHUO Xiuming

doi:10.14033/j.cnki.cfmr.2023.36.013

Abstract：Objective:To explore the effect of Esmolol combined with early goal directed therapy(EGDT)on septic cardiomyopathy patients.Method:The data of 96 patients with septic cardiomyopathy admitted to the Fujian Medical University Provincial College of Clinical Medicine from January 2021 to December 2022 were retrospectively analyzed.They were divided into control group(n=48)and observation group(n=48)according to different treatment methods.Both groups were given conventional treatment,the control group was given EGDT,and the observation group was given Esmolol based on the control group.Inflammatory factors,cardiac function indexes,circulatory indexes before treatment and after 24 h of treatment,adverse reactions and mortality were compared between the two groups.Result:After 24 h of treatment,the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After 24 h of treatment,the levels of creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI)and cardiac troponin T(cTnT)in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After 24 h of treatment,the mean arterial pressure(MAP)of the observation group was higher than that of the control group,heart rate(HR)was lower than that of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The 28 d mortality of the observation group was lower than that of the control group,and the difference was statistically significant(x2=4.360,P=0.037).Conclusion:Esmolol combined with EGDT can significantly reduce inflammation reaction and myocardial damage in patients with septic cardiomyopathy,improve cardiac function,reduce mortality,and do not increase adverse reactions.