Effects of Chaihu Shugan Powder Modified on Emotional States and Related Neurotransmitters in Patients with Anxiety Insomnia

ZHANG Yan

doi:10.14033/j.cnki.cfmr.2023.36.011

Abstract：Objective:To explore the effects of Chaihu Shugan Powder Modified on emotional state and related neurotransmitters in patients with anxiety insomnia.Method:A total of 120 patients with anxiety insomnia who were treated in Beijing Jiangong Hospital from September 2020 to October 2022 were selected and divided into control group and observation group by computer randomized method,with 60 patients in each group.According to the shedding and elimination criteria,a total of 58 cases were included in the observation group and 57 cases in the control group.The control group was treated with Estazolam Tablets,and the observation group was treated with Chaihu Shugan Powder Modified on the basis of the control group.After 4 weeks of treatment,the clinical efficacy,sleep quality,anxiety,levels of related neurotransmitters and the occurrence of adverse reactions were compared between the two groups.Result:The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in scores of Pittsburgh sleep quality index(PSQI)and Hamilton anxiety scale(HAMA)between the two groups(P>0.05).After treatment,PSQI scores and HAMA scores in both groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in 5-hydroxytryptamine(5-HT),glutamic acid(Glu),dopamine(DA)and gamma-aminobutyric acid(GABA)between the two groups(P>0.05).After treatment,the levels of 5-HT and GABA in two groups were higher than those before treatment,the levels of Glu and DA were lower than those before treatment,and the levels of 5-HT and GABA in observation group were higher than those in control group,the levels of Glu and DA were lower than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The Chaihu Shugan Powder Modified can improve the treatment effect of anxiety insomnia,improve sleep quality,relieve anxiety,adjust the level of neurotransmitters,so as to adjust the balance of sleep-wake cycle without increasing adverse reactions.