Effect of Fuke Zhixueling Tablets Combined with Dydrogesterone Tablets in the Treatment of Abnormal Uterine Bleeding in Perimenopause

CHEN Lili; MING Xiaoqiong

doi:10.14033/j.cnki.cfmr.2023.36.009

Abstract：Objective:To investigate the effect of Fuke Zhixueling Tablets combined with Dydrogesterone Tablets in the treatment of abnormal uterine bleeding in perimenopausal.Method:A total of 94 patients with perimenopausal abnormal uterine bleeding admitted to CR&WISCO General Hospital from August 2020 to August 2022 were selected and divided into study group and control group by random number table method,with 47 cases in each group.The control group was treated with Dedrogestone Tablets,and the study group was treated with Fuke Zhixueling Tablets combined with Dedrogestone Tablets.The clinical efficacy,sex hormone level,prostaglandin E2(PGE2)level,menstrual volume,hemostatic time,regular menstrual time and incidence of adverse reactions were compared between the two groups.Result:The total effective rate of the study group was 93.62％,which was higher than 78.72％of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in follicle-stimulating hormone(FSH),progesterone(P),estradiol(E2)and luteinizing hormone(LH)between the two groups(P>0.05).After treatment,the levels of FSH,P,E2 and LH in two groups were lower than those before treatment,and those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in PGE2 level between the two groups(P>0.05).After treatment,the level of PGE2 in the two groups were lower than those before treatment,and the study group was lower than that in the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the score of pictorial blood loss assessment chart(PBAC)between the two groups(P>0.05).After treatment,PBAC scores in both groups were lower than those before treatment,and the study group was lower than that in the control group,the differences were statistically significant(P<0.05).The time of hemostasis and menstrual regularity in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 4.26％,which was lower than 8.51％in the control group,the difference was statistically significant(P>0.05).Conclusion:Patients with abnormal uterine bleeding were treated with Fuke Zhixueling Tablets combined with Dydrogesterone Tablets,which could improve clinical efficacy,improve sex hormone levels and PGE2 levels,reduce menstrual volume,shorten hemostasis time and menstrual regularity time,and would not increase adverse reactions.