Clinical Effect of Jinxing Jiangya Prescription Combined with Felodipine in the Treatment of Essential Hypertension

GU Huijie; FANG Jun

doi:10.14033/j.cnki.cfmr.2023.36.002

Abstract：Objective:To investigate the clinical effect of Jinxing Jiangya Prescription combined with Felodipine in the treatment of essential hypertension.Method:A total of 102 patients with essential hypertension admitted to Kunshan Hospital of Traditional Chinese Medicine from February 2020 to February 2023 were selected as study objects,they were divided into control group and experimental group according to random number table method,with 51 patients in each group.The control group received Felodipine treatment,and the experimental group received Jinxing Jiangya Prescription combined with Felodipine treatment.Blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)],total effective rate of clinical treatment,traditional Chinese medicine symptom score,lipid level[high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglyceride(TG)],quality of life,total incidence of adverse reactions were compared between the two groups.Result:After treatment,the levels of DBP and SBP in both groups during the day and at night were significantly decreased,and those in the experimental group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of experimental group was 96.08％,which was higher than 82.35％of control group,the difference was statistically significant(P<0.05).After treatment,traditional Chinese medicine symptom scores of both groups decreased,that of the experimental group was lower than that of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in HDL-C,LDL-C,TC and TG levels between the two groups(P>0.05).After treatment,the HDL-C level increased in both groups,and that in the experimental group was higher than that in the control group;after treatment,the LDL-C,TC and TG levels decreased in both groups,and those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the scores of each dimension and total score of quality of life in both groups were increased,and those in the experimental group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in experimental group was 11.76％,the total incidence of adverse reactions in control group was 7.84％,and there was no significant difference between the two groups(P>0.05).Conclusion:Jinxing Jiangya Prescription combined with Felodipine in the treatment of essential hypertension patients can effectively reduce the blood pressure level of patients,improve the clinical therapeutic effect,reduce the traditional Chinese medicine symptom score,improve the blood lipid level of patients,improve the quality of life,will not increase the occurrence of adverse reactions.