Application Value of Fecal SDC2 Gene Methylation Combined with CEA Detection in the Differential Diagnosis of Early Colorectal Cancer

NIU Tianbao; LIANG Jia; LIU Dechun

doi:10.14033/j.cnki.cfmr.2023.35.019

Abstract：Objective:To explore the application value of fecal syndecan-2(SDC2)gene methylation combined with carcinoembryonic antigen(CEA)detection in the differential diagnosis of early colorectal cancer.Method:A total of 86 patients with suspected early colorectal cancer who treated in the Department of Gastrointestinal Surgery,the First Affiliated Hospital of Henan University of Science and Technology from August 2020 to October 2022 were selected as the study group,and 32 patients with benign colorectal lesions who treated in our hospital during the same period were selected as the control group.Fecal SDC2 gene methylation detection and CEA level detection were performed respectively,the pathological results were used as the gold standard to calculate the diagnostic efficacy of two detection methods and combined detection for early colorectal cancer.Result:The proportion of positive fecal SDC2 gene methylation and CEA levels in the study group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The sensitivity and accuracy of fecal SDC2 gene methylation combined with serum CEA in the detection of early colorectal cancer were higher than those of serum CEA detection,and the differences were statistically significant(P<0.05);however,there were no statistically significant differences in the sensitivity,specificity and accuracy of fecal SDC2 gene methylation combined with serum CEA in the detection of early colorectal cancer compared with those of fecal SDC2 gene testing,the specificity of fecal SDC2 gene methylation combined with serum CEA compared with that of serum CEA in the detection of early colorectal cancer(P>0.05).Conclusion:Fecal SDC2 gene methylation detection and CEA levels have certain diagnostic efficacy for early colorectal cancer,and combined detection is helpful to improve the diagnostic sensitivity.