Expression of Serum Cholyglycine and Total Bile Acid in Liver Cirrhosis and Their Predictive Value for Liver Cancer

WANG Bin; ZENG Hui; QIU Li

doi:10.14033/j.cnki.cfmr.2023.34.018

Abstract：Objective:To investigate the expression of serum cholyglycine(CG)and total bile acid(TBA)in liver cirrhosis and their predictive value for liver cancer.Method:Sixty-eight patients with liver cirrhosis admitted to Wuhan Seventh Hospital from June 2021 to June 2022 were selected as the observation group,68 patients with viral hepatitis admitted at the same period were selected as the control group,and 68 healthy physical examiner patients at the same period were selected as the health group.Serum CG and TBA levels were detected in three groups.Patients in the observation group were followed up for half a year,and they were divided into liver cancer group and non-liver cancer group according to whether they developed liver cancer.General data of the two groups were collected.The serum CG and TBA levels of the three groups and patients with different disease stages in observation group were compared.The general information,serum CG and TBA levels of liver cancer group and non-liver cancer group were compared.The clinical value of serum CG and TBA in predicting liver cancer was analyzed.Result:Serum CG and TBA levels in observation group were higher than those in control group and healthy group,and the differences were statistically significant(P<0.05).The levels of serum CG and TBA in the decompensated stage were higher than those in the compensation stage,and the differences were statistically significant(P<0.05).The 68 patients with liver cirrhosis were followed up for six months,and 12 cases developed into liver cancer,with the incidence was 17.65%(12/68).The proportion of decompensated period in the liver cancer group was higher than that in the non-liver cancer group,and the duration of liver cirrhosis was longer than that in the non-liver cancer group,and the differences were statistically significant(P<0.05).The levels of serum CG and TBA in liver cancer group were higher than those in non-liver cancer group,and the differences were statistically significant(P<0.05).The receiver operating characteristic(ROC)curve was drawn,and the area under the curve(AUC)of CG,TBA and combined detection for predicting liver cancer were 0.813,0.832 and 0.959 respectively,combined detection had higher prediction value.Conclusion:Serum CG and TBA are highly expressed in liver cirrhosis,which can well evaluate the disease of liver cirrhosis,and have certain predictive value for the occurrence of liver cancer,and the combined detection has higher predictive value.