Effect of Ginkgolide Combined with Alteplase Thrombolysis in the Treatment of Acute Cerebral Infarction

LIU Zongpin; CHEN Liping

doi:10.14033/j.cnki.cfmr.2023.34.011

Abstract：Objective:To observe the effect of Ginkgolide combined with Alteplase thrombolysis in the treatment of acute cerebral infarction.Method:A total of 110 patients with acute cerebral infarction treated in Datian General Hospital from January 2019 to August 2022 were selected.According to the random number table method,they were divided into study group of 55 cases and control group of 55 cases.Both groups were given general treatment,the control group was given thrombolytic therapy with Alteplase for Injection,and the study group was given Ginkgolide Injection on the basis of the control group.The daily activity ability,limb motor function,neural function deficit,disease condition,platelet index before and after treatment,complications and clinical effect were compared between the two groups.Result:After treatment,Barthel index(BI)and Fugl-Meyer limb motor function scale(FMA)scores of both groups were higher than those before treatment,and BI and FMA scores of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the National Institutes of Health stroke scale(NIHSS)and modified Rankin scale(mRS)scores in both groups were lower than those before treatment,and the NIHSS and mRS scores in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the platelet aggregation rate and platelet adhesion rate of the two groups were lower than those before treatment,and the platelet aggregation rate and platelet adhesion rate of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The incidence of complication of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:The effect of Ginkgolide combined with Alteplase thrombolysis in the treatment of patients with acute cerebral infarction is good,which can significantly promote the recovery of nervous system and limb function,improve the platelet aggregation state.