Effect of Standard Channel Percutaneous Nephrolithotomy Combined with Flexible Ureteroscopy Holmium Laser Lithotripsy on Patients with Upper Urinary Tract Stones

GUAN Dejia; SUN Zhongkai; LIU Jianxun; LUO Honghe

doi:10.14033/j.cnki.cfmr.2023.34.009

Abstract：Objective:To study the effect of standard channel percutaneous nephrolithotomy(SPCNL)combined with flexible ureteroscopy holmium laser lithotripsy(FURS)on patients with upper urinary tract stones(UUTC).Method:A total of 73 UUTC patients treated in Dabu County People's Hospital from May 2020 to May 2022 were selected as the study objects.The patients'visit number were numbered,and they were divided into observation group(n=38)and control group(n=35)according to random number table method.The control group was given SPCNL,and the observation group was given SPCNL combined with FURS.Perioperative indexes,stone clearance rate,urination condition,renal function indexes before operation and after 7 d of operation and complications were compared between the two groups.Result:The operation time of the observation group was longer than that of the control group,the intraoperative blood loss volume was less than that of the control group,the hospitalization time was shorter than that of control group,and the stone clearance rate was higher than that of the control group,the differences were statistically significant(P<0.05).After 7 d of operation,the maximum urine flow rate(Qmax),maximum urethral pressure(MUP)and single urine volume(UV)of the two groups were higher than those before operation,and the Qmax,MUP and UV of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).After 7 d of operation,serum creatinine(Scr),serum uric acid(UA)and β2-microglobulin(β2-MG)levels in the two groups were lower than those before operation,and the levels of UA,Scr and β2-MG in observation group were lower than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of postoperative complications between the two groups(P>0.05).Conclusion:SPCNL combined with FURS can effectively improve the stone clearance rate of UUTC patients,restore postoperative urination condition and renal function,and do not increase complications.