Application of Atorvastatin Combined with Clopidogrel in Transient Ischemic Attack

LI Xiang

doi:10.14033/j.cnki.cfmr.2023.34.007

Abstract：Objective:To explore the application effect of Atorvastatin combined with Clopidogrel in transient ischemic attack(TIA).Method:A total of 80 patients with TIA admitted to Guihang Guiyang Hospital were selected from January to December 2021.They were divided into control group and observation group according to the sampling inspection method,40 cases in each group.The control group was treated with Clopidogrel,and the observation group was treated with Atorvastatin on the basis of control group.The clinical efficacy,coagulation function,blood lipid indexes,inflammatory factors,carotid plaque condition before and after treatment,incidence of TIA at 3 months,6 months and 12 months after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of observation group(90.00%)was higher than that of control group(72.50%),and the difference was statistically significant(P<0.05).After treatment,there were no statistically significant in prothrombin time(PT)and platelet count(PLT)between the two groups(P>0.05),and triglyceride(TG)and total cholesterol(TC)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).At 3 months,6 months and 12 months after treatment,the incidences of TIA in observation group were lower than that in control group,and the differences were statistically significant(P<0.05).After treatment,the number of carotid plaque,low echo plaque and strong echo plaque in the observation group were lower than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ2=0.139,P=0.709).Conclusion:Atorvastatin combined with Clopidogrel is effective in the treatment of TIA patients,which can reduce ischemic attacks,improve the levels of inflammatory factors and blood lipids,and stabilize plaques.