Clinical Effect Analysis of Tiotropium Bromide Combined with High-dose Seretide in the Treatment of Severe Bronchial Asthma Complicated with Chronic Obstructive Pulmonary Disease

LIN Juan

doi:10.14033/j.cnki.cfmr.2016.36.004

Abstract：Objective:To analyze the clinical effect of Tiotropium Bromide combined with high-dose Seretide in the treatment of severe bronchial asthma complicated with chronic obstructive pulmonary disease.Method:From January 2014 to June 2015 in our hospital,98 patients with severe bronchial asthma complicated with COPD were randomly divided into control group and experimental group,each group 49 patients.The control group used the compound Ipratropium Bromide aerosol and medium-dose Fluticasone.The experimental group was treated with Tiotropium dry powder aerosol and high-dose Seretide.The treatment effect was compared between the two groups.Result:In both groups,the ACT scores were significantly improved at 1 week and 4 months after treatment,the differences were statistically significant(P<0.05).However,in both groups 1 week and 4 months after treatment,there were not statistically significant difference in ACT scores(P>0.05).After 4 month of treatment,the FEV1,FEV1/FVC and FEV1% predicated value of the experimental group were better than those of the control group,the differences were statistically significant(P<0.05).After 4 month of treatment,the quality of life score in the experimental group was (90.2±4.7) points, significantly higher than that of the control group,the difference was statistically significant(P<0.05).The acute exacerbation interval of the experimental group was (70.1±5.8)d,better than (43.6±6.9)d of the control group,the difference was statistically significant(P<0.05).The number of acute exacerbations in the experimental group was also significantly lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The treatment of severe bronchial asthma with chronic obstructive pulmonary disease(COPD) by Tiotropium Bromide combined with high-dose Seretide can effectively improve the asthma and improve the lung function and quality of life.It is worth to be popularized and applied in clinical practice.